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Phosphatidylserine: Introduction, Health Benefits and Usage

Phosphatidylserine: Introduction, Health Benefits and Usage

Phosphatidylserine is a substance essential to maintaining the integrity of the cell membrane and a basic component of acetylcholine, the neuroscientist on which a series of important brain activities, such as the transmission of brain signals to the muscles, the regulation of heartbeat and breathing, and the filtering of information that arrives at the cerebral level. It is known that phosphatidylserine is a major component of gray matter, accounting for 30% of its mass.

Over the past few years, over 3,000 papers have been published on the importance of fosfatidylserine, plant origin, improved memory processes, and increased attention, concentration, and mental acuity. Phosphatidylserine increases the ability to metabolize glucose in the brain, the most important source of energy for it.

  • Promotes the health of brain functions;
  • Supports neural communication;
  • Can improve mental acuity;
  • Helps maintain a good mood;
  • Promotes mental functions.

Phosphatidylserine, an essential nutrient for brain structure and function, and a healthy nerve cell block. Phosphatidylserine, along with essential fatty acids, including omega-3, promotes brain functions such as memory, learning, balance, and mood. One of the most important compounds for neurons is phosphatidylserine (PS).

It accounts for about 10% of the neuronal cell membranes and over time it can be done in the body, the level of this important nutrient often decreases with age. Phosphatidylserine helps maintain the structure and function of neurons and help prevent age-related decline.

Phosphatidylserine along with other phospholipids in the brain improves cellular communication between neurons. This can help improve memory, concentration, and overall thinking ability.

Phosphadilyserin is a nutritional supplement that was originally used to improve brain activity. Some of the studies have shown that this chemical improves cognitive abilities in older people. In addition, phosphatidylsilina has been proposed as a substance with “anti-corticolysis” capacities – two studies conducted by Italian scientists have shown that phosphatidylserine can reduce the secretion of cortisol following an intense effort. It has recently begun to be used by bodybuilders as an anticatabolic substance and hoping to improve the anabolic response.

But these hopes have not proved to be real, according to a study published in January 2006 in Medicine & Science in Sport & Exercise – “Effects of Phosphatidylserine on Exercise Capacity during Cycling in Active Males”. However, this study has shown a positive aspect of the use of this substance. In the study, forty men received 750 mg of phosphatidylserine in order to observe changes in performance.

They were instructed to pedal in three series of 10 minutes at 45, 55 and 65% of VO2 max respectively (maximum aerobic effort capacity), followed by an effort at 85% of VO2 max to exhaust. Five days after this trial, for 11 days, the subjects received either a placebo or phosphatidylserine.

At the end of this period, the effort test was carried out again. Laboratory determinations targeted a series of parameters that track performance, respiratory and cardiac effort, blood composition – all of these were measured before, during and after the stress test.

They showed that subjects who consumed phosphatidylserine had a significant increase in the duration of the maximal effort to exhaustion – from 7 minutes and 51 seconds to 9 minutes and 55 seconds at least.

However, with respect to the change in biological parameters specific to exercise (in close association with cortisol secretion), no significant difference was observed. The conclusion of this study was that phosphatidylserine has ergogenic effects, but the mechanism remains to be established through further studies.

General Data

Phosphatidylserine is a phospholipid (a fatty, complex substance) that can be found in all cells of the body, but especially in the neuronal membrane, accounting for about 70% of the mass of the nervous tissue. Although the body has the ability to synthesize phosphatidylserine, much of it comes from eating. The first products based on phosphatidylserine were extracted from the bovine brain, but it is now preferred that sources of cabbage and soybeans.


At the cerebral level, phosphatidylserine stimulates dopamine secretion (inhibitory neurotransmitter, brain motor deficiency in the brain is associated with Parkinson’s disease), supports acetylcholine production, reduces cortisol levels (the major hormone secreted by the body in intense stress), and boosts glucose metabolism in the brain the main brain fuel).
Directions Alzheimer’s and memory problems:

Administration of phosphatidylserine-containing products in people diagnosed with Alzheimer’s for at least 6-12 weeks may reduce some of the symptoms. Effects are especially manifested in patients whose condition has been discovered in the early stages. Phosphatidylserine improves memory strength, linguistic abilities, and attention in people experiencing a cognitive decline associated with age.

ADHD: Studies in children diagnosed with ADHD have highlighted both increased attention and reduced impulsivity with phosphatidylserine.

Increased effort resistance: The use of phosphatidylserine-containing products supports the metabolism of muscle cells in intense physical effort, reducing the sensation of muscle fever, and reduces the amount of cortisol secreted in the body during intense physical effort.

Pharmaceutical preparations Phosphatidylserine can be purchased as such or in combination with other active substances in complex formulas. It can be purchased as capsules, soft gelatin capsules. The recommended daily dose is between 100 and 300 mg daily in divided doses.  

Interactions and side effects Careful administration are recommended for people taking anticoagulant medication, as phosphatidylserine may increase their effect. Caution should be exercised when administering acetylsalicylic acid products over very long periods

Phosphatidylserine and mental functions

The economic wealth of Western society is reflected in the consumption of food. Our food is full of sugars, proteins, and fats. But the basic components of the feed are so-called phospholipids. Phospholipids are the basis of all cell membranes, and most of the biological activities take place even though these cell membranes, where phospholipids function as an ointment regulating physiological activities.

It is a paradox, that despite the overconsumption of food, the phospholipid content in them is very low. Over the past decade, it has been demonstrated that besides the general properties of each member of the family of phospholipids, they also have specific functions that are the subject of medical research.

The most important member of the phospholipid family is FOSFATIDILSERINE (PS), which is the functional component of our brain. It presents a number of functions of neural activity and therefore medical research focuses on the influence of phosphatidylserine on the most important brain functions, such as memory, memory quality, and learning.

Another important component of phospholipids is FOSFATIDIC ACID (PA). This acid plays an active role in the membranes of brain neurons and nerve processes. Recent studies talk about phosphatidic acid as a “neural messenger.”

Scientists distinguish two areas of memory disturbance. – the first is related to the natural, normal, loss of memory due to age; – the other is related to loss of memory due to Alzheimer’s disease and other pshice disorders that are irreversible. The relationship between age and memory problems was followed in all the studies studied.

Because of this link, scientists have proposed dietary supplementation by supplementing phosphatidylserine and phosphatidic acid. It has been demonstrated that the administration of both substances has high biological accessibility and after about 30 minutes of administration, the level of this substance has been increased in the blood serum, with further absorption in the liver and later in the brain.

Studies in Europe and the US show that phosphatidylserine can play an important role in supporting human cognitive functions in supporting judgment, abstract thinking, memory, behaviors, and personality.

Phosphosphate is a lecithin complex of soy and phosphatidic acid. This natural nutritional supplement can improve the ability to master stress and cope with its long-lasting effect.

The study by Prof. D. Hellhmmerem of Trier University in Germany demonstrated that daily administration of 400 mg of phosphatidylserine (4 capsules of phosphosercaps) contributed to the significant mitigation of stress hormones in response to the stress test. The tested people worked better, no wakefulness or ability to act was achieved.

Phosphatidylserine is, therefore. considered an important cornerstone of brain cell membranes. It has been proven to play an important role in cessation or cessation of age-related cognitive impairments, supports short-term memory and the ability to learn new tasks.

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