Glucocil has Alpha-lipoic acid, it is sometimes recommended as a dietary supplement for patients with type 1 or type 2 diabetes, metabolic syndrome, PCOS or other conditions related to dysfunctional blood glucose regulation.
Alpha lipoic acid, which may also be referred to as “ALA,” is a fatty acid and an antioxidant naturally synthesized within the human body. This substance is also available as an orally administered supplement. Studies have shown that alpha lipoic acid can improve some diabetes-related symptoms and can help control blood sugar levels within a normal range. However, this supplement has not been approved as a drug for the treatment of diabetes.
Furthermore, alpha lipoic acid can cause side effects for some people. Here is an overview of alpha-lipoic acid and its effects for people with diabetes.
Functions of alpha-lipoic acid
Alpha-lipoic acid is a dithiol compound naturally produced by the body. It could also derive from some food sources, including broccoli, spinach and brewer’s yeast.
This nutrient had been shown to protect against oxidizing processes in the body. Alpha-lipoic acid also plays an important role in enzymatic reactions within mitochondria. Studies have shown that alpha lipoic acid has different effects on the human body, including moderation of cholesterol levels of health, suppression of virus transcription, antioxidant effects, anti-inflammatory effects and more.
It is believed to have anti-aging as well as detoxification benefits. The Natural Medicines Database reports that people have used alpha-lipoic acid supplements for many different purposes, including liver disease, cancer, HIV and chronic fatigue syndrome.
Does Glucocil help to lower the level of blood sugar?
Blood sugar control is one of the most effective ways to prevent developing diabetic complications. Research indicates that Glucocil has alpha lipoic acid which can help to decrease elevated blood glucose levels.
In particular, in a study published in 2011, researchers found that treatment with alpha-lipoic acid led to lower levels of fasting blood glucose and lower levels of postprandial plasma glucose among patients with type 2 diabetes. Another study examined the effects of alpha lipoic acid on insulin sensitivity in non-diabetic women with polycystic ovarian syndrome. The women were given a controlled release supplement of 600mg twice a day for 16 weeks.
After the end of the treatment period, participants experienced a 13.5% improvement in insulin sensitivity, as well as improved serum triglycerides. In another study, the researchers found that treating mice fed a high-fat diet with alpha-lipoic acid led to better glucose metabolism and insulin resistance.
However, none of these studies is sufficient to validate the ability of alpha-lipoic acid to lower glycemia in all diabetic patients. Researchers are continuing to explore this topic.
Benefits of ALA in Glucocil for diabetes
Studies indicate that alpha lipoic acid may have specific benefits for people with diabetes. Among the claimed benefits of alpha-lipoic acid for diabetes:
- Lower Fasting Blood Glucose – Results from numerous research studies support the idea that taking an alpha-lipoic acid supplement can reduce fasting blood sugar levels among individuals with diabetes. The national drug database reports that alpha lipoic acid is considered “possibly effective” for this purpose.
- Improved glucose metabolism – Studies have also shown that alpha lipoic acid can improve the rate at which glucose is metabolized.
- Improved insulin sensitivity – Researchers believe that alpha lipoic acid may increase insulin sensitivity, thereby supporting the reduction in blood sugar levels further.
- Improvement/prevention of diabetic neuropathy – Multiple studies have indicated that patients taking an alpha-lipoic acid supplement experience reduced lipid peroxidation-induced hyperglycemia in sciatic nerve and brain tissues, which may protect against neuropathy.
Fifty percent of individuals diagnosed with this disorder will experience symptoms of diabetic distal sensory-motor neuropathy. ALA is considered to be effective in the treatment of this condition, although it is generally administered intravenously and not a food supplement.
Other studies have indicated that ALA administration can also reduce the symptoms of existing neuropathies, possibly by increasing circulation. Peripheral neuropathy is a common side effect of diabetes, causing a painful sensation in the limbs and extremities. Some experience this as a burning, itchy, tingling or numbness in the fingers and toes.
The other important ingredient in Glucocil is Proprietary Mulberry Leaf Extract
According to a study published in February 2017, the consumption of mulberry leaf extract would improve glucose tolerance and lower insulin levels in subjects with normal blood glucose levels, thus lowering the risk of type II diabetes.
Consumption of excessive amounts of calories associated with lack of physical activity contributes significantly to weight gain, increasing the risk of developing type II diabetes.
In 2013, a large European study assessing the effects of diet on health found an association between the consumption of sugary drinks and the risk of type II diabetes. Weight gain had a significant effect on this risk of type II diabetes, while that of consumption of sweet sodas was relatively low. Dietary sugars and carbohydrates play an important role because calories from these foods promote fat storage and hunger.
Glucocil contains the leaves of white mulberry (Morus alba) has been used in traditional Chinese medicine for millennia. They contain a natural substance called DNJ (1-deoxynojirimycin) which reduces the transformation of polysaccharides into glucose and thus slows the entry of sugar into the blood. But if you are taking up to 600 mg per day of alpha lipoic acid for three weeks has been shown to significantly reduce the symptoms of diabetic peripheral neuropathy in a study.
ALA can also improve the symptoms of autonomic cardiovascular neuropathy (PUÒ), which occurs in about twenty-five percent of people diagnosed with diabetes. This condition can cause analysis of reduced cardiac variability and increase the risk of death from a cardiovascular accident or otherwise.
A multi-center, randomized, double-blind placebo-controlled study examined the effects of ALA on 187 diabetics divided into four groups. One group received 600 mg of alpha lipoic acid daily, another received 1,200 mg daily, one third received 1,800 mg and the fourth was given a placebo.
At the end of five weeks, those taking the supplement saw a 50% decrease in symptoms, compared to a 32% decrease in those taking the placebo. The researchers concluded that, “Oral treatment with alpha-lipoic acid for improvement of five-week neuropathic symptoms and deficits in 187 patients with symmetrical diabetic polyneuropathy.”
Recommended dose of alpha-lipoic acid for diabetics
The following assays have been used in the latest research studies without serious adverse effects.
- Alpha-lipoic acid for type 2 diabetes – oral dosages of 300 to 1800 mg of ALA per day for up to 2 years; Intravenous doses of 500 to 600 mg of alpha-lipoic acid in saline for up to 3 weeks.
- Neuropathy – Oral doses of 600 to 1800 mg of ALA per day for up to 4 years.
- Altered glucose tolerance – Intravenous doses of 600 mg of ALA 250 mL of saline solution once a day for up to 3 weeks.
Side effects and adverse reactions
Alpha-lipoic acid is generally well tolerated, but side effects are possible.
These are some of the most common side effects experienced by consumers taking oral alpha-lipoic acid supplements:
- He retched
People taking intravenous alpha lipoic acid also experienced localized pain and redness at the injection site.
In most cases, there were mild reactions to both the oral and intravenous forms of alpha-lipoic acid. If you experience any significant side effects while taking this supplement, stop taking it and tell your doctor.
Taking alpha-lipoic acid for diabetes safely
Consumers with diabetes should be particularly cautious when taking alpha-lipoic acid. Studies have shown that this supplement can lower blood glucose levels and increase insulin sensitivity
When combined with anti-diabetes drugs, this can lead to hypoglycemia. If you plan to take this diabetes supplement, ask your doctor to determine if your other diabetes medications need to be adjusted accordingly. You should also avoid taking this supplement with other supplements that are known to cause hypoglycaemia.
If you experience symptoms of hypoglycaemia, such as sweating, trembling and dizziness, check your blood sugar and take steps to correct the problem if you find that your sugar is too low.